Elucidation of Novel Structural Scaffold in Rohu TLR2 and Its Binding Site Analysis with Peptidoglycan, Lipoteichoic Acid and Zymosan Ligands, and Downstream MyD88 Adaptor Protein
Figure 5
Illustration of the interaction of PGN, LTA, and zymosan with the modeled 3D structure of rohu TLR2-ECD by AutoDock 4.0 program. At B5 region, interaction of PGN-I with TLR2-ECD (a) and PGN-DAP with TLR2-ECD (b); at B6 region, interaction of PGN-I with TLR2-ECD (c) and PGN-DAP with TLR2-ECD (d); interaction of LTA with TLR2-ECD (e) and zymosan with TLR2-ECD (f). The TLR2-ECD was shown in ribbon and ligands (PGN, LTA, and zymosan) were shown in solid form. Amino acid number depicted in the figure was shown as per the matured protein (after removal of the signal peptide).
