Elucidation of Novel Structural Scaffold in Rohu TLR2 and Its Binding Site Analysis with Peptidoglycan, Lipoteichoic Acid and Zymosan Ligands, and Downstream MyD88 Adaptor Protein
Figure 6
Illustration of the interaction of PGN, LTA, and zymosan with the modeled 3D structure of rohu TLR2-ECD by GOLD 4.1 program. Interaction of (a) PGN-I and TLR2-ECD at LRR16-19; (b) PGN-II and TLR2-ECD at LRR16-19; (c) PGN-DAP and TLR2-ECD at LRR16-19; (d) PGN-II and TLR2-ECD at LRR8-10; (e) zymosan and TLR2-ECD at LRR20-CT; (f) LTA and TLR2-ECD at LRR12-14. Rohu TLR2-ECD model was shown as line and ligands (PGN, LTA, and zymosan) are shown as stick.
