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BioMed Research International
Volume 2013 (2013), Article ID 185317, 5 pages
http://dx.doi.org/10.1155/2013/185317
Research Article

Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever?

1Department of Internal Medicine, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
2Department of Medical Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
3Department of Hematology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
4Department of Rheumatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Received 28 April 2013; Revised 5 June 2013; Accepted 9 June 2013

Academic Editor: Akinori Nakamura

Copyright © 2013 Ali Ugur Uslu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The purpose of the present study is to determine the association between neutrophil/lymphocyte ratio and both subclinical inflammation and amyloidosis in familial Mediterranean fever. Methods. Ninety-four patients with familial Mediterranean fever and 60 healthy volunteers were included in the study. Of the patients, 12 had familial Mediterranean fever related amyloidosis. The neutrophil/lymphocyte ratio of the patients was obtained from the hematology laboratory archive. Results. The neutrophil/lymphocyte ratio was significantly higher among persons with familial Mediterranean fever compared to healthy individuals ( ). Also, neutrophil/lymphocyte ratio was significantly higher in patients with amyloidosis than in amyloidosis-free patients ( ). Since NLR was evaluated in nonamyloid and amyloid stages of the same patient population (type 1 phenotype), we obtained significant statistical differences ( versus , , resp.). With the cutoff value of neutrophil/lymphocyte ratio >2.21 and AUC = 0.734 ( ), it was a reliable marker in predicting the development of amyloidosis. Conclusion. The neutrophil/lymphocyte ratio, an emerging marker of inflammation, is higher in patients with familial Mediterranean fever in attack-free periods. The neutrophil/lymphocyte ratio may be a useful marker in predicting the development of amyloidosis.