About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 185317, 5 pages
http://dx.doi.org/10.1155/2013/185317
Research Article

Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever?

1Department of Internal Medicine, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
2Department of Medical Biochemistry, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
3Department of Hematology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey
4Department of Rheumatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Received 28 April 2013; Revised 5 June 2013; Accepted 9 June 2013

Academic Editor: Akinori Nakamura

Copyright © 2013 Ali Ugur Uslu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Ben-Chetrit and M. Levy, “Familial Mediterranean fever,” The Lancet, vol. 351, no. 9103, pp. 659–664, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Fonnesu, C. Cerquaglia, M. Giovinale et al., “Familial Mediterranean Fever: a review for clinical management,” Joint Bone Spine, vol. 76, no. 3, pp. 227–233, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. I. Ben-Zvi and A. Livneh, “Chronic inflammation in FMF: markers, risk factors, outcomes and therapy,” Nature Reviews Rheumatology, vol. 7, no. 2, pp. 105–112, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Korkmaz, H. Özdogan, O. Kasapçopur, and H. Yazici, “Acute phase response in familial Mediterranean fever,” Annals of the Rheumatic Diseases, vol. 61, no. 1, pp. 79–81, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. H. J. Lachmann, B. Şengül, T. U. Yavuzşen et al., “Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations,” Rheumatology, vol. 45, no. 6, pp. 746–750, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Bilginer, T. Akpolat, and S. Ozen, “Renal amyloidosis in children,” Pediatric Nephrology, vol. 26, no. 8, pp. 1215–1227, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Zahorec, “Ratio of neutrophil to lymphocyte counts–rapid and simple parameter of systemic inflammation and stress in critically ill,” Bratislavske Lekarske Listy, vol. 102, supplement 1, pp. 5–14, 2001. View at Scopus
  8. I. Tasoglu, D. Sert, N. Colak, et al., “Neutrophil-lymphocyte ratio and the platelet-lymphocyte ratio predict the limb survival in critical limb ischemia,” Clinical and Applied Thrombosis/Hemostasis. In press.
  9. M. Biyik, R. Ucar, Y. Solak, et al., “Blood neutrophil-to-lymphocyte ratio independently predicts survival in patients with liver cirrhosis,” European Journal of Gastroenterology & Hepatology, vol. 25, pp. 435–441, 2013.
  10. E. Pras, A. Livneh, J. E. Balow Jr., et al., “Clinical differences between North African and Iraqi Jews with familial Mediterranean fever,” American Journal of Medical Genetics, vol. 75, pp. 216–219, 1998.
  11. A. Soriano and R. Manna, “Familial Mediterranean fever: new phenotypes,” Autoimmunity Reviews, vol. 12, pp. 31–37, 2012.
  12. A. Nakamura, M. Matsuda, K.-I. Tazawa, Y. Shimojima, and S.-I. Ikeda, “Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever,” Internal Medicine, vol. 46, supplement 15, pp. 1247–1249, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Dundar, A. Kiraz, B. Balta, et al., “The role of TNF-α and PAI-1 gene polymorphisms in familial Mediterranean fever,” Modern Rheumatology, vol. 23, pp. 140–145, 2013.
  14. Y. Berkun, S. Padeh, B. Reichman et al., “A single testing of serum amyloid a levels as a tool for diagnosis and treatment dilemmas in familial Mediterranean fever,” Seminars in Arthritis and Rheumatism, vol. 37, no. 3, pp. 182–188, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Lidar and A. Livneh, “Familial mediterranean fever: clinical, molecular and management advancements,” Netherlands Journal of Medicine, vol. 65, supplement 9, pp. 318–324, 2007. View at Scopus
  16. K. Yildirim, H. Uzkeser, M. Keles et al., “Relationship between serum interleukin-1β levels and acute phase response proteins in patients with familial Mediterranean fever,” Biochemia Medica, vol. 22, no. 1, pp. 109–113, 2012. View at Scopus
  17. S. Kiraz, I. Ertenli, M. Arici et al., “Effects of colchicine on inflammatory cytokines and selectins in familial Mediterranean fever,” Clinical and Experimental Rheumatology, vol. 16, supplement 6, pp. 721–724, 1998. View at Scopus
  18. M. Onsrud and E. Thorsby, “Influence of in vivo hydrocortisone on some human blood lymphocyte subpopulations. I. Effect on natural killer cell activity,” Scandinavian Journal of Immunology, vol. 13, no. 6, pp. 573–579, 1981. View at Scopus
  19. R. S. Hotchkiss and I. E. Karl, “The pathophysiology and treatment of sepsis,” New England Journal of Medicine, vol. 348, no. 2, pp. 138–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Demir, “The relationship between neutrophil lymphocyte ratio and non-dipper hypertension,” Clinical and Experimental Hypertension, 2013. View at Publisher · View at Google Scholar
  21. M. A. R. Muhmmed Suliman, A. A. Bahnacy Juma, A. A. Ali Almadhani, A. V. Pathare, S. S. A. Alkindi, and F. Uwe Werner, “Predictive value of neutrophil to lymphocyte ratio in outcomes of patients with acute coronary syndrome,” Archives of Medical Research, vol. 41, no. 8, pp. 618–622, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. S. R. Walsh, E. J. Cook, F. Goulder, T. A. Justin, and N. J. Keeling, “Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer,” Journal of Surgical Oncology, vol. 91, no. 3, pp. 181–184, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. K. M. Sarraf, E. Belcher, E. Raevsky, A. G. Nicholson, P. Goldstraw, and E. Lim, “Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer,” Journal of Thoracic and Cardiovascular Surgery, vol. 137, no. 2, pp. 425–428, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. W. He, C. Yin, G. Guo, et al., “Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer,” Medical Oncology, vol. 30, supplement 1, p. 439, 2013.
  25. C. S. D. Roxburgh and D. C. McMillan, “Role of systemic inflammatory response in predicting survival in patients with primary operable cancer,” Future Oncology, vol. 6, supplement 1, pp. 149–163, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. M. J. Proctor, D. S. Morrison, D. Talwar et al., “An inflammation-based prognostic score (mGPS) predicts cancer survival independent of tumour site: a Glasgow Inflammation Outcome Study,” British Journal of Cancer, vol. 104, supplement 4, pp. 726–734, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Koch, H. Fohlin, and S. Sörenson, “Prognostic significance of C-reactive protein and smoking in patients with advanced non-small cell lung cancer treated with first-line palliative chemotherapy,” Journal of Thoracic Oncology, vol. 4, supplement 3, pp. 326–332, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. A. M. Al Murri, C. Wilson, A. Lannigan et al., “Evaluation of the relationship between the systemic inflammatory response and cancer-specific survival in patients with primary operable breast cancer,” British Journal of Cancer, vol. 96, supplement 6, pp. 891–895, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Ikeda, H. Furukawa, H. Imamura et al., “Poor prognosis associated with thrombocytosis in patients with gastric cancer,” Annals of Surgical Oncology, vol. 9, supplement 3, pp. 287–291, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. J. S. Yudkin, C. D. A. Stehouwer, J. J. Emeis, and S. W. Coppack, “C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, supplement 4, pp. 972–978, 1999. View at Scopus
  31. E. Buyukkaya, M. F. Karakas, E. Karakas, et al., “Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome,” Clinical and Applied Thrombosis/Hemostasis, 2012. View at Publisher · View at Google Scholar
  32. M. Celikbilek, S. Dogan, O. Ozbakır, et al., “Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis,” Journal of Clinical Laboratory Analysis, vol. 27, supplement 1, pp. 72–76, 2013.