Reconstruction and Analysis of Human Kidney-Specific Metabolic Network Based on Omics Data

Table 2

Selected DEG in DKD for FVA analysis.

Gene symbol	Entrez gene ID	FC (glomeruli)	FC (tubuli)	Reaction	Gene name
LPL	4023	−9.18501	−4.38411	LPS; LPS2	Lipoprotein lipase
GCNT3	9245	2.12739	1.847147	CORE4GTg	Glucosaminyl (N-acetyl) transferase 3
NNMT	4837	4.353618	7.890573	NNMT	Nicotinamide N-methyltransferase
RRM2	6241	2.526649	3.055954	RNDR1; RNDR2; RNDR3; RNDR4	Ribonucleotidereductase M2 polypeptide
B3GNT1	10678	−2.28274	−1.53357	B3GNT11g	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
ASNS	440	−1.53775	2.724576	DEDOLP1_U; EX_asn_L(e); FT	Asparagine synthetase

Note: These DEG were selected from a previous study [4], and their flux spans of metabolic reactions were detected to fluctuate markedly (Figure 5). It suggests the essential role of these genes in DKD process. Knocking out of these genes may cause metabolism alterations and affect the emergence of DKD. The first column is the gene symbol of DEG; the second column is the Entrez gene ID; the third and fourth columns are the fold change value for glomeruli and tubuli cell, respectively; the fifth column shows the representative affected reactions, and the sixth column is gene name.