About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 190178, 8 pages
http://dx.doi.org/10.1155/2013/190178
Research Article

Analysis of Pregnancy-Associated Plasma Protein A Production in Human Adult Cardiac Progenitor Cells

1Department of Gynaecology, Obstetrics and Urologic Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
2Department of Molecular Medicine, Cenci Bolognetti Foundation, Pasteur Institute, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
3Department of Medical Surgical Sciences and Biotechnology, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy
4Department of Cardiocirculatory Pathophysiology, Anesthesiology and General Surgery, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy

Received 29 April 2013; Revised 9 September 2013; Accepted 10 September 2013

Academic Editor: Sergiy Sukhanov

Copyright © 2013 Piera D’Elia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Bach, “The insulin-like growth factor system: towards clinical applications,” The Clinical Biochemist Reviews, vol. 25, no. 3, pp. 155–164, 2004.
  2. M. Mahmoudabady, M. Mathieu, K. Touihri et al., “Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy,” BMC Cardiovascular Disorders, vol. 9, article 1471, p. 49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Messina, L. De Angelis, G. Frati et al., “Isolation and expansion of adult cardiac stem cells from human and murine heart,” Circulation Research, vol. 95, no. 9, pp. 911–921, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. R. R. Smith, L. Barile, H. C. Cho et al., “Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens,” Circulation, vol. 115, no. 7, pp. 896–908, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Chimenti, R. R. Smith, T.-S. Li et al., “Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice,” Circulation Research, vol. 106, no. 5, pp. 971–980, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Chimenti, E. Forte, F. Angelini, A. Giacomello, and E. Messina, “From ontogenesis to regeneration: learning how to instruct adult cardiac progenitor cells,” Progress in Molecular Biology and Translational Science, vol. 111, pp. 109–137, 2012. View at Publisher · View at Google Scholar
  7. R. Gaetani, L. Barile, E. Forte et al., “New perspectives to repair a broken heart,” Cardiovascular and Hematological Agents in Medicinal Chemistry, vol. 7, no. 2, pp. 91–107, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. R. R. Makkar, R. R. Smith, K. Cheng et al., “Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial,” The Lancet, vol. 379, no. 9819, pp. 895–904, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Chimenti, G. Rizzitelli, R. Gaetani et al., “Human cardiosphere-seeded gelatin and collagen scaffolds as cardiogenic engineered bioconstructs,” Biomaterials, vol. 32, no. 35, pp. 9271–9281, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Gaetani, G. Rizzitelli, I. Chimenti et al., “Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application,” Journal of Cellular and Molecular Medicine, vol. 14, no. 5, pp. 1071–1077, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Takeda, I. Manabe, Y. Uchino et al., “Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload,” Journal of Clinical Investigation, vol. 120, no. 1, pp. 254–265, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. C. Bendall, M. H. Stewart, P. Menendez et al., “IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro,” Nature, vol. 448, no. 7157, pp. 1015–1021, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. J. B. Lawrence, C. Oxvig, M. T. Overgaard et al., “The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 6, pp. 3149–3153, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. L. S. Laursen, M. T. Overgaard, R. Soe et al., “Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A,” FEBS Letters, vol. 504, no. 1-2, pp. 36–40, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Kumar, S. Mohan, J. Newton et al., “Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism,” Journal of Biological Chemistry, vol. 280, no. 45, pp. 37782–37789, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. B.-K. Chen, K. M. Leiferman, M. R. Pittelkow, M. T. Overgaard, C. Oxvig, and C. A. Conover, “Localization and regulation of pregnancy-associated plasma protein A expression in healing human skin,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 9, pp. 4465–4471, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Brambati, M. C. M. MacIntosh, B. Teisner et al., “Low maternal serum levels of pregnancy associated plasma protein A (PAPP-A) in the first trimester in association with abnormal fetal karyotype,” British Journal of Obstetrics and Gynaecology, vol. 100, no. 4, pp. 324–326, 1993. View at Scopus
  18. P. Meloni, I. D'Angeli, J. Piazze et al., “First trimester PAPP-A levels associated with early prediction of pregnancy induced hypertension PAPP-A to detect gestational hypertension,” Hypertension in Pregnancy, vol. 28, no. 4, pp. 361–368, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. H. B. Boldt and C. A. Conover, “Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs,” Growth Hormone and IGF Research, vol. 17, no. 1, pp. 10–18, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Oxvig, O. Sand, T. Kristensen, G. J. Gleich, and L. Sottrup-Jensen, “Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein,” Journal of Biological Chemistry, vol. 268, no. 17, pp. 12243–12246, 1993. View at Scopus
  21. A. Bayes-Genis, C. A. Conover, M. T. Overgaard et al., “Pregnancy-associated plasma protein A as a marker of acute coronary syndromes,” New England Journal of Medicine, vol. 345, no. 14, pp. 1022–1029, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Bayes-Genis, C. A. Conover, and R. S. Schwartz, “The insulin-like growth factor axis: a review of atherosclerosis and restenosis,” Circulation Research, vol. 86, no. 2, pp. 125–130, 2000. View at Scopus
  23. A. Funayama, T. Shishido, S. Netsu et al., “Serum pregnancy-associated plasma protein A in patients with heart failure,” Journal of Cardiac Failure, vol. 17, no. 10, pp. 819–826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. O. Schulz, M. Reinicke, J. Krämer et al., “Pregnancy-associated plasma protein A values in patients with stable cardiovascular disease: use of a new monoclonal antibody-based assay,” Clinica Chimica Acta, vol. 412, no. 11-12, pp. 880–886, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. K. K. Iversen, A. S. Teisner, B. Teisner et al., “Pregnancy Associated Plasma Protein A, a Novel, Quick, and Sensitive Marker in ST-Elevation Myocardial Infarction,” American Journal of Cardiology, vol. 101, no. 10, pp. 1389–1394, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Conti, C. Carrozza, E. Capoluongo et al., “Insulin-like growth factor-1 as a vascular protective factor,” Circulation, vol. 110, no. 15, pp. 2260–2265, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. P. D'Elia, D. Marzioni, M. Castellucci, C. Moccia, and A. Pala, “Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimester of pregnancy: biochemical and morphological observations,” Placenta, vol. 33, no. 11, pp. 942–945, 2012. View at Publisher · View at Google Scholar
  28. I. Chimenti, R. Gaetani, L. Barile et al., “Isolation and expansion of adult cardiac stem/progenitor cells in the form of cardiospheres from human cardiac biopsies and murine hearts,” Methods in Molecular Biology, vol. 879, pp. 327–338, 2012. View at Publisher · View at Google Scholar
  29. A. Pala, A. Di Ruzza, L. Curtilli et al., “Interference of an α2 component in immunological determinations of pregnancy-specific β1 glycoprotein in serum,” Clinica Chimica Acta, vol. 168, no. 1, pp. 33–46, 1987. View at Scopus
  30. S. Glerup, S. Kløverpris, L. S. Laursen et al., “Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor,” Journal of Biological Chemistry, vol. 282, no. 3, pp. 1769–1778, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Suzuki, J. Takada, K. Isaka, M. Takayama, and J. G. Grudzinskas, “Isolation of pregnancy-associated plasma protein A,” Placenta, vol. 18, supplement 1, pp. 13–25, 1997.
  32. T.-S. Li, K. Cheng, S.-T. Lee et al., “Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair,” Stem Cells, vol. 28, no. 11, pp. 2088–2098, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Forte, F. Miraldi, I. Chimenti et al., “TGFβ-dependent epithelial-to-mesenchymal transition is required to generate cardiospheres from human adult heart biopsies,” Stem Cells and Development, vol. 21, no. 17, pp. 3081–3090, 2012. View at Publisher · View at Google Scholar
  34. A. Abbas, P. J. Grant, and M. T. Kearney, “Role of IGF-1 in glucose regulation and cardiovascular disease,” Expert Review of Cardiovascular Therapy, vol. 6, no. 8, pp. 1135–1149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. L. S. Laursen, M. T. Overgaard, K. Weyer et al., “Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity: reversible adhesion is mediated by two neighboring short consensus repeats,” Journal of Biological Chemistry, vol. 277, no. 49, pp. 47225–47234, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. Q.-P. Qin, S. Kokkala, J. Lund, N. Tamm, L.-M. Voipio-Pulkki, and K. Pettersson, “Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy,” Clinical Chemistry, vol. 51, no. 1, pp. 75–83, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. P. J. Hogg, “Disulfide bonds as switches for protein function,” Trends in Biochemical Sciences, vol. 28, no. 4, pp. 210–214, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. D. V. Serebryanaya, N. N. Tamm, E. V. Koshkina, and A. G. Katrukha, “Immunochemical properties of PAPP-A isolated from human atherosclerotic coronary arteries,” in America Association Clinical Chemistry Annual Meeting, Washington, DC, USA, July 2008.