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BioMed Research International
Volume 2013 (2013), Article ID 190382, 7 pages
Research Article

Over, and Underexpression of Endothelin 1 and TGF-Beta Family Ligands and Receptors in Lung Tissue of Broilers with Pulmonary Hypertension

1Unidad Laguna, Universidad Autónoma Agraria Antonio Narro, 27010 Torreón, COAH, Mexico
2Posgrado del Centro de Estudios Justo Sierra, Surutato, 80600 Badiraguato, SIN, Mexico
3Universidad Autónoma Metropolitana Xochimilco, Calzada del Hueso 1100, Villa Quietud, 04960 Coyoacan, DF, Mexico
4Posgrado Biología Experimental, Universidad Autónoma Metropolitana Iztapalapa, 09340 Iztapalapa, Mexico
5FMVZ, Benemérita Universidad Autónoma de Puebla, 72482 Tecamachalco, PUE, Mexico
6Departamento de Inmunología, Instituto Nacional de Cardiología Dr. Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, 140080 Tlalpan, DF, Mexico

Received 30 April 2013; Revised 13 July 2013; Accepted 10 September 2013

Academic Editor: Coline van Moorsel

Copyright © 2013 Norma Dominguez-Avila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Transforming growth factor beta (TGFβ) is a family of genes that play a key role in mediating tissue remodeling in various forms of acute and chronic lung disease. In order to assess their role on pulmonary hypertension in broilers, we determined mRNA expression of genes of the TGFβ family and endothelin 1 in lung samples from 4-week-old chickens raised either under normal or cold temperature conditions. Both in control and cold-treated groups of broilers, endothelin 1 mRNA expression levels in lungs from ascitic chickens were higher than levels from healthy birds ( ), whereas levels in animals with cardiac failure were intermediate. Conversely, TGFβ2 and TGFβ3 gene expression in lungs were higher in healthy animals than in ascitic animals in both groups ( ). TGFβ1, TβRI, and TβRII mRNA gene expression among healthy, ascitic, and chickens with cardiac failure showed no differences ( ). BAMBI mRNA gene expression was lowest in birds with ascites only in the control group as compared with the values from healthy birds ( ).