Table 1: Survival outcome in experimental models of hepatic warm ischemia-reperfusion injury and hepatic steatosis.

AuthorAnimalSteatosis model% steatosisType of steatosisDuration of ischemia
(mins, type of ischemia)
Duration of reperfusion (hours)Survival of steatotic livers
(lean livers)

Ellett et al. [29]MouseHFD30–60MaS35 (total)24 hours31% (85%)1
Yamagami et al. [30]Rat2CDD40–60MaS45 (total)7 days33.3%
He et al. [31]MouseHFD50–60MaS45 (total)24 hours33% (100%)1
Caraceni et al. [32]RatCDD50–60MaS60 (total)7 days60% (100%)1
Selzner et al. [33]MouseCDD>60Mixed60 (total)14 days80% (100%)1
Caraceni et al. [34]RatCDD>60MaS60 (total)7 days64% (100%)1
Hakamada et al. [35]RatCDD>60MaS30, 60, or 90 (total)7 days95%, 10%, and 5%
(100%, 90%, and 35%)1
Hui et al. [36]RatCDD>70MaS30, 45, or 60 (total)7 days75%, 20%, and 0
(100%, 90%, and 70%)1
Takahashi et al. [37]CanineHFD7–99MaS60 (total)24 hours100% in <30% MaS
0 in >30% MaS
(100%)1

CDD: choline-deficient diet; HFD: high-fat diet; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; P < 0.05 versus lean livers; no lean group in study.