The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review

Table 1

Survival outcome in experimental models of hepatic warm ischemia-reperfusion injury and hepatic steatosis.

Author	Animal	Steatosis model	% steatosis	Type of steatosis	Duration of ischemia; (mins, type of ischemia)	Duration of reperfusion (hours)	Survival of steatotic livers; (lean livers)
Ellett et al. [29]	Mouse	HFD	30–60	MaS	35 (total)	24 hours	31% (85%)^1
Yamagami et al. [30]	Rat^2	CDD	40–60	MaS	45 (total)	7 days	33.3%
He et al. [31]	Mouse	HFD	50–60	MaS	45 (total)	24 hours	33% (100%)^1
Caraceni et al. [32]	Rat	CDD	50–60	MaS	60 (total)	7 days	60% (100%)^1
Selzner et al. [33]	Mouse	CDD	>60	Mixed	60 (total)	14 days	80% (100%)^1
Caraceni et al. [34]	Rat	CDD	>60	MaS	60 (total)	7 days	64% (100%)^1
Hakamada et al. [35]	Rat	CDD	>60	MaS	30, 60, or 90 (total)	7 days	95%, 10%, and 5%; (100%, 90%, and 35%)^1
Hui et al. [36]	Rat	CDD	>70	MaS	30, 45, or 60 (total)	7 days	75%, 20%, and 0; (100%, 90%, and 70%)^1
Takahashi et al. [37]	Canine	HFD	7–99	MaS	60 (total)	24 hours	100% in <30% MaS; 0 in >30% MaS; (100%)^1

CDD: choline-deficient diet; HFD: high-fat diet; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; 1P < 0.05 versus lean livers; 2no lean group in study.