Table 4: Survival outcome in experimental models of orthotopic liver transplantation and hepatic steatosis.

AuthorAnimalSteatosis model% steatosisType of steatosisDuration of ischemia (mins)PerfusateDuration of reperfusionSurvival of recipients of steatotic livers (lean livers)

Astarcioglu et al. [48]RatCDD30–60MaS60 or 540ns7 days87.5 and 0 (100 and 100%)1
Hayashi et al. [49]RatCDD30–60MaS60 to 540UWUp to 7 days0 (75%)1
Cheng et al. [50]Rat2CMDD<30 to
>30
Mixed33–39UWns33.3% (100%)1,3
He et al. [31]MouseHFD50–60MaS180Saline7 days0 (40%)1
Schmeding et al. [51]Rat2CDD>50MaS720UWUp to 7 days68%
Berthiaume et al. [52]RatCMDD>60MaS720UWUp to 7 days0 (85%)1
Morioka et al. [53]RatHFD40–50Mixed120HTK7 days Survival4

CDD: choline-deficient diet; CMDD: choline-methionine-deficient diet; HFD: high-fat diet; HTK: histidine-tryptophan-ketoglutarate solution; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; ns: not stated; Saline: normal saline solution; UW: University of Wisconsin solution.
P < 0.05 versus lean livers; no lean group in study; decreased survival in >60% macrovesicular steatosis compared to <60% macrovesicular, >60% microvesicular steatosis or >60% mixed steatosis; decreased survival in recipients of 30 and 70% steatotic liver volume compared to recipients of volume matched lean livers.