The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review

Table 5

Histological finding in experimental models of orthotopic liver transplantation and hepatic steatosis.

Author	Animal	Steatosis model	% steatosis	Type of steatosis	Duration of ischemia; (mins)	Perfusate	Duration of reperfusion; (mins)	Outcome measures	Results in recipients of steatotic livers (lean livers)
Astarcioglu et al. [48]	Rat	CDD	30–60	MaS	60 or 540	ns	120	Histo	↑ Parenchymal injury
Hayashi et al. [49]	Rat	CDD	30–60	MaS	60 to 540	UW	Up to 7 days	Histo	↑ Sinusoidal congestion and necrosis
He et al. [31]	Mouse	HFD	50–60	MaS	180	Saline	24 hours	HIS	2.4 ± 0.05 (1.8 ± 0.05)^1
Schmeding et al. [51]	Rat^2	CDD	>50	MaS	720	UW	Up to 7 days	Histo	Severe necrosis
Morioka et al. [53]	Rat	HFD	40–50	Mixed	120	HTK	48 hours	Histo	↑ Sinusoidal congestion and necrosis

CDD: choline-deficient diet; HFD: high-fat diet; Histo: histology; HIS: histological injury score; HTK: histidine-tryptophan-ketoglutarate solution; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; ns: not stated; Saline: normal saline solution; UW: University of Wisconsin solution.
1P < 0.05 versus lean livers; 2no lean group in study.