Table 5: Histological finding in experimental models of orthotopic liver transplantation and hepatic steatosis.

AuthorAnimalSteatosis model% steatosisType of steatosisDuration of ischemia
(mins)
PerfusateDuration of reperfusion
(mins)
Outcome measuresResults in recipients of steatotic livers (lean livers)

Astarcioglu et al. [48]RatCDD30–60MaS60 or 540ns120Histo Parenchymal injury
Hayashi et al. [49]RatCDD30–60MaS60 to 540UWUp to 7 daysHisto Sinusoidal congestion and necrosis
He et al. [31]MouseHFD50–60MaS180Saline24 hoursHIS2.4 ± 0.05 (1.8 ± 0.05)1
Schmeding et al. [51]Rat2CDD>50MaS720UWUp to 7 daysHistoSevere necrosis
Morioka et al. [53]RatHFD40–50Mixed120HTK48 hoursHisto Sinusoidal congestion and necrosis

CDD: choline-deficient diet; HFD: high-fat diet; Histo: histology; HIS: histological injury score; HTK: histidine-tryptophan-ketoglutarate solution; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; ns: not stated; Saline: normal saline solution; UW: University of Wisconsin solution.
P < 0.05 versus lean livers; no lean group in study.