The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review

Table 6

Liver function tests in experimental models of orthotopic liver transplantation and hepatic steatosis.

Author	Animal	Steatosis model	% steatosis	Type of steatosis	Duration of ischemia; (mins)	Perfusate	Duration of reperfusion; (mins)	Outcome measures	Results in recipients of steatotic livers (lean livers)
Astarcioglu et al. [48]	Rat	CDD	30–60	MaS	60 or 540	ns	120	ALT; AST; Bile production	1640 ± 482 (396 ± 54 IU/L)^1; 2270 ± 684 (580 ± 70 IU/L)^1; 6.2 ± 0.5 (23.8 ± 1.8 cm/10 min)^1
He et al. [31]	Mouse	HFD	50–60	MaS	180	Saline	24 hours	ALT	10000 ± 1500 (5000 ± 200 IU/L)^1
Schmeding et al. [51]	Rat^2	CDD	>50	MaS	720	UW	Up to 7 days	ALT; AST	1200 ± 900 IU/L; 1500 ± 1200 IU/L
Morioka et al. [53]	Rat	HFD	40–50	Mixed	120	HTK	48 hours	ALT	700 (200 IU/L)^1

ALT: alanine aminotransferase; AST: aspartate aminotransferase; CDD: choline-deficient diet; HFD: high-fat diet; HTK: histidine-tryptophan-ketoglutarate solution; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; ns: not stated; Saline: normal saline solution; UW: University of Wisconsin solution.
1P < 0.05 versus lean livers; 2no lean group in study.