Table 6: Liver function tests in experimental models of orthotopic liver transplantation and hepatic steatosis.

AuthorAnimalSteatosis model% steatosisType of steatosisDuration of ischemia
(mins)
PerfusateDuration of reperfusion
(mins)
Outcome measuresResults in recipients of steatotic livers (lean livers)

Astarcioglu et al. [48]RatCDD30–60MaS60 or 540ns120ALT
AST
Bile production
1640 ± 482 (396 ± 54 IU/L)1  
2270 ± 684 (580 ± 70 IU/L)1  
6.2 ± 0.5 (23.8 ± 1.8 cm/10 min)1
He et al. [31]MouseHFD50–60MaS180Saline24 hoursALT10000 ± 1500 (5000 ± 200 IU/L)1
Schmeding et al. [51]Rat2CDD>50MaS720UWUp to 7 daysALT
AST
1200 ± 900 IU/L  
1500 ± 1200 IU/L
Morioka et al. [53]RatHFD40–50Mixed120HTK48 hoursALT700 (200 IU/L)1

ALT: alanine aminotransferase; AST: aspartate aminotransferase; CDD: choline-deficient diet; HFD: high-fat diet; HTK: histidine-tryptophan-ketoglutarate solution; MaS: macrovesicular steatosis; Mixed: presence of both macrovesicular and microvesicular steatosis; ns: not stated; Saline: normal saline solution; UW: University of Wisconsin solution.
P < 0.05 versus lean livers; no lean group in study.