Research Article
Gene Silencing of 4-1BB by RNA Interference Inhibits Acute Rejection in Rats with Liver Transplantation
Table 2
The levels of AST, LDH, ALT, and T-BIL in plasma of BN recipients rats 7 days after liver transplantation.
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The recombination vector of lentivirus containing shRNA targeting the 4-1BB gene was constructed. The liver transplantation was performed using the two-cuff technique. BN recipient rats were infected by the recombinant LVs. The blood samples were gathered 7 days after liver transplantation. The liver function markers were tested by using the automatic biochemical meter. Model: liver transplantation model group; LV-NC: negative-control shRNA group; LV-sh4-1BB1: pcDNA-CMV-sh4-1BB-Lentivector1 group. Data were expressed as means ± SD, . # compared with the sham (control) group; * compared with the LV-NC group. |