The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations
Figure 7
Structural models of the Sp SPT G385F mutant mimic. (a) Sp SPT holostructure (PDB:2JG2) and the L-serine external aldimine structure (PDB:2W8J). Residues from monomer one are shown in white, residues from monomer two are shown in teal, the PLP cofactor is shown in green, and the mutated glycine to phenylalanine residue is shown in yellow. The models and figures were generated using PyMol software.
