Demethylation of Cancer/Testis Antigens and CpG ODN Stimulation Enhance Dendritic Cell and Cytotoxic T Lymphocyte Function in a Mouse Mammary Model

Figure 3

Granzyme B and perforin release from CTLs cocultured with DCs treated using different protocols (IL-2, P1A-specific peptide, CpG ODN, or P1A-specific peptide + CpG ODN). Both granzyme B and perforin secretion were markedly increased upon treatment with P1A-specific + CpG ODN (𝑃<0.01). Values are the means ± SD (𝑛=3) of three individual experiments. ^∗𝑃<0.05 and ^∗∗𝑃<0.01 versus control; ^#𝑃<0.05 and ^##𝑃<0.01 versus group treated with P1A-specific peptide or CpG ODN.