Demethylation of Cancer/Testis Antigens and CpG ODN Stimulation Enhance Dendritic Cell and Cytotoxic T Lymphocyte Function in a Mouse Mammary Model

Figure 5

Antitumor Effect of H-2L^d-restricted P1A-specific CTLs in vivo. We established an mouse model bearing 4T1 cells. (a) H-2L^d-restricted P1A-specific CTLs significantly inhibited 4T1 cell growth in BALB/C mice treated with P1A-specific peptide + CpG ODN. (b) Tumor weight in the P1A-specific peptide + CpG ODN treated group was significantly lower than that of the control groups. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus Control; ^#𝑃<0.05, ^##𝑃<0.01 versus group treated with P1A-specific peptide or CpG ODN.

(a)

(b)