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BioMed Research International
Volume 2013 (2013), Article ID 197398, 12 pages
http://dx.doi.org/10.1155/2013/197398
Research Article

Design Expert Supported Mathematical Optimization and Predictability Study of Buccoadhesive Pharmaceutical Wafers of Loratadine

1Bengal College of Pharmaceutical Sciences and Research, West Bengal University of Technology, B.R.B. Sarani, Durgapur, West Bengal 713212, India
2College of Pharmacy, Roseman University of Health Sciences, 11 Sunset Way, Henderson, NV 89052, USA
3S. Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand 248001, India
4School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Delhi Road (NH-24), Moradabad, Uttar Pradesh 244 102, India

Received 4 April 2013; Accepted 2 May 2013

Academic Editor: Yoshinori Onuki

Copyright © 2013 Prithviraj Chakraborty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine (LOR). Methods. Experiments were performed according to a 32 factorial design to evaluate the effects of buccoadhesive polymer, sodium alginate ( ), and lactose monohydrate as ingredient, of hydrophilic matrix former ( ) on the bioadhesive force, disintegration time, percent (%) swelling index, and time taken for 70% drug release ( ). The effect of the two independent variables on the response variables was studied by response surface plots and contour plots generated by the Design-Expert software. The desirability function was used to optimize the response variables. Results. The compatibility between LOR and the wafer excipients was confirmed by differential scanning calorimetry, FTIR spectroscopy, and X-ray diffraction (XRD) analysis. Bioadhesion force, measured with TAXT2i texture analyzer, showed that the wafers had a good bioadhesive property which could be advantageous for retaining the drug into the buccal cavity. Conclusion. The observed responses taken were in agreement with the experimental values, and Loratadine wafers were produced with less experimental trials, and a patient compliant product was achieved with the concept of formulation by design.