Research Article
Design Expert Supported Mathematical Optimization and Predictability Study of Buccoadhesive Pharmaceutical Wafers of Loratadine
Table 3
Response parameter for Loratadine-loaded buccoadhesive pharmaceutical wafers prepared as per 32 factorial design.
| | Formulation code | Formulation composition | Bioadhesive force | Disintegration time | % Swelling | () | | Sodium alginate (% w/v) | Lactose monohydrate (% w/v) | () (gm) | () (min) | index () | (sec) |
| | FNA 1 | 1.00 | 0.00 | 28.6 | 1.09 | 59.71 | 90 | | FNA 2 | 1.00 | 0.50 | 35.9 | 1.22 | 59.58 | 90 | | FNA 3 | 1.00 | 1.00 | 25.9 | 1.247 | 60.08 | 240 | | FNA 4 | 1.50 | 0.00 | 40 | 1.367 | 83.39 | 90 | | FNA 5 | 1.50 | 0.50 | 65 | 1.683 | 83.32 | 120 | | FNA 6 | 1.50 | 1.00 | 81.2 | 2.067 | 83.81 | 210 | | FNA 7 | 0.50 | 0.00 | 61.3 | 0.316 | 49.51 | 30 | | FNA 8 | 0.50 | 0.50 | 38.9 | 0.453 | 49.68 | 90 | | FNA 9 | 0.50 | 1.00 | 34.4 | 0.476 | 50.18 | 180 |
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