Table 1: Sum of toxicity patterns matching phenytoin-induced metabolite changes.

ToxicityPhenytoin, low dosePhenytoin, high dose

Bone, osteoblast inhibitor1
CNS, GABA receptor antagonist2
Kidney, diuretic effect1
Liver cholestasis2
Liver toxicity2
Liver, enzyme induction15
Liver, paracetamol-derived toxicity1
Thyroid, indirect effects12

Grand total513

Tabulation of the number of specific patterns associated with a given toxicity that: (1) have a confirmed match (see Section 2) with the metabolite profile of phenytoin treated animals at either the high or low dose, and (2) matched the metabolite profile of treated animals with a median correlation greater than 0.5 at either dose. Data taken from [25].