Table 2: Sum of toxicity patterns matching cyclosporin A-induced metabolite changes.

ToxicityCyclosporin A, low doseCyclosporin A, high dose

Blood, anemia1
Bone, osteoblast inhibitor2
GI tract, duodenum, iron deficiency11
Immune system, immunosuppression11
Kidney, diuretic effect1
Kidney, interstitial nephritis1
Kidney, glomerular tubular defect1
Liver, paracetamol-like toxicity22
Nervous system, serotonin receptor antagonist1
Spleen, methemoglobinaemia3

Grand total414

See the legend for Table 1.