Table 6: Summary of metabolite profiling and comparison with know toxicities.

DrugTargetRat study standard findingsHuman clinical findingsMMtox prediction

CaptoprilKidneyYesYesYes (*)
LisinoprilKidneyYesYesYes (*)
Cyclosporin AKidneyYesYesYes
DoxorubicinKidneyYesYesYes
PhenytoinKidneyNoNoNo
CaptoprilLiverNoYesYes
Cyclosporin ALiverYesYesYes
DoxorubicinLiverYesYesYes
LisinoprilLiverNoNoNo
PhenytoinLiverNoYesYes
Cyclosporin AAnemiaYesYesYes
DoxorubicinAnemiaYesYesYes
CaptoprilBone marrowYesYesYes
LisinoprilPlateletYesYesYes

The treatments with these compounds were used to define some of the patterns for kidney toxicity.