Time Series Expression Analyses Using RNA-seq: A Statistical Approach
Figure 8
(a) A set of top cooperative TDE genes detected by Glass-d-score with FDR 0.05 as a candidate of cooperative gene pairs in coexpression in zebrafish data. Glass-d-score and corresponding FDR at cutoff 0.05 by resampling procedure under the null hypothesis that there are no TDE patterns across samples and those are shuffled with 1,000 repetitions. (b) One specific gene in coupled temporal dynamics with low expression level via SETI and Glass-d-score from (a). Glass-d-score is robust in identifying coexpressed genes over time at low expression levels.
