Table 1: Administration routes and pharmacokinetic parameters of representative antifungal agents belonging to the major families of compounds.

Drug familyDrugAdm. routeaPharmacokinetic parametersReferences
Oral bioavailability (%)   
μg/mL
AUCc mg·h/LProtein binding (%)Half time (h)Elimination

AzolesFluconazoleOral>900.7400.010–1227–31Urine[35, 37]
ItraconazoleOral>551.129.299.821–64Hepatic[35, 37]
VoriconazoleOral>904.620.360.0 6Renal[35, 37, 38]
PosaconazoleOral>987.817.099.015–35Feces[35, 39]

EchinocandinsCaspofunginIV<59.5–12.193.5–100.596.010.6Urine[20, 35, 40, 41]
MicafunginIV<57.1–10.959.9–111.399.811–17Feces[20, 35, 40, 41]
AnidulafunginIV<53.4–7.544.4–104.584.018.1–25.6Feces[20, 35, 40, 41]

PolyenesAmphotericin BIV<51.5–2.113–17>956.8–50Feces[35, 42]

Nucleoside analoguesFlucytosineOral76–89806243–6Renal[31, 35]

Adm. route indicates administration route; fluconazole, itraconazole, and voriconazole can be administered by both intravenous and oral routes; IV: intravenous; b : maximal concentration; cAUC: area under the curve.