Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

Table 4

Pharmacokinetic parameters of some lead drugs.

Drug	Available forms	Experimental organisms	Pharmacokinetic parameters						References
			Oral bioavailability (%)	𝐶max^b (μg/mL)	𝑡max^c (h)	Protein binding (%)	Half time (h)	Elimination
E1210	Oral/IV^a	Mice	57.5	0.11	0.5	High	2.2	nr^d	[80]
Albaconazole	Oral	Healthy human volunteers	nr^d	5–80; (proportional to dose)	2–4	98	30–56	Feces	[81, 82]
Isavuconazonium	Oral	Healthy human volunteers	Very high	1.03; (100 mg dose)	0.75–1	98	56–77	Feces	[81–83]
Isavuconazole	IV^a	Healthy human volunteers	nr^d	1.45; (100 mg dose)	1.3–5	98	76–104	Feces	[81–83]

aIV: intravenous; ^b𝐶_max: maximal concentration; ^c𝑡_max: time to reach maximal plasma concentrations after oral administration; ^dnr: not reported.