Table 4: Pharmacokinetic parameters of some lead drugs.

DrugAvailable formsExperimental organismsPharmacokinetic parametersReferences
Oral bioavailability (%) (μg/mL) (h)Protein binding (%)Half time (h)Elimination

E1210Oral/IVaMice57.50.110.5High2.2nrd[80]
AlbaconazoleOralHealthy human volunteersnrd5–80
(proportional to dose)
2–49830–56Feces[81, 82]
IsavuconazoniumOralHealthy human volunteersVery high1.03
(100 mg dose)
0.75–19856–77Feces[8183]
IsavuconazoleIVaHealthy human volunteersnrd1.45
(100 mg dose)
1.3–59876–104Feces[8183]

IV: intravenous; b : maximal concentration; c : time to reach maximal plasma concentrations after oral administration; dnr: not reported.