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BioMed Research International
Volume 2013 (2013), Article ID 206525, 7 pages
http://dx.doi.org/10.1155/2013/206525
Research Article

Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma

1302 Hospital of PLA, Beijing 100039, China
2Navy General Hospital, Beijing 100048, China

Received 11 May 2013; Revised 29 August 2013; Accepted 2 September 2013

Academic Editor: Koichiro Wada

Copyright © 2013 Xiaodong Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Aquaporin (AQP) 3 and AQP 5 are involved in tumorigenesis and tumor progression of several tumor types. Aim. To investigate expression patterns and clinical significance of AQP3 and AQP5 in hepatocellular carcinoma (HCC). Methods. Immunohistochemistry was performed to detect the expression of AQP3 and AQP5 in HCC tissues. Results. Immunohistochemistry analysis showed the increased expression of AQP3 and AQP5 protein levels in HCC tissues compared with their adjacent nonneoplastic tissues (both ). In addition, combined AQP3 and AQP5 protein expression was significantly associated with serum AFP ( ), tumor stage ( ), and tumor grade ( ). Moreover, HCC patients highly expressing both AQP3 and AQP5 proteins had worse 5-year disease-free survival and 5-year overall survival ( and 0.005, resp.). Furthermore, the Cox proportional hazards model showed that combined AQP3 and AQP5 protein expression was an independent poor prognostic factor for both 5-year disease-free survival ( ) and 5-year overall survival ( ) in HCC. Conclusion. Our data suggest for the first time that the aberrant expression of AQP3 and AQP5 proteins may be strongly related to tumor progression and prognosis in patients with HCC. The overexpression of AQP3 in combination with upregulation of AQP5 may be an unfavorable prognostic factor for HCC.