Research Article

Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma

Figure 2

Disease-free survival and overall survival curves for two groups defined by low and high expression of AQP3 ((a) and (b)) or AQP5 ((c) and (d)) and for four groups defined by combined expression of AQP3 and AQP5 ((e) and (f)), in patients with HCC. The patients with high AQP3 and AQP5 expression had a significantly shorter 5-year overall and disease-free survival rate than those with low AQP3 and AQP5 expression ( and , resp.). In addition, the results by pairwise comparisons showed that the statistically significant difference of overall and disease-free survival existed between AQP3-high/AQP5-high patients and any of other three groups ( and 0.005, resp.). In all four groups, AQP3-high/AQP5-high patients had the poorest prognosis.
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