Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma

Table 1

Association of AQP3 and AQP5 expression with clinicopathological features of 130 hepatocellular carcinoma patients.

Clinicopathological features	Case	AQP3-high (n, %)	P	AQP5-high (n, %)	P	AQP3-high/AQP5-high (n, %)	P
Age (years)
≤50	72	47 (65.28)	NS	40 (55.56)	NS	30 (41.67)	NS
>50	58	35 (60.34)		33 (56.90)		22 (37.93)
Gender
Male	96	62 (64.58)	NS	54 (56.25)	NS	40 (41.67)	NS
Female	34	20 (58.82)		19 (55.88)		12 (35.29)
Serum AFP
Positive	72	64 (88.89)	0.002	43 (59.72)	NS	45 (62.50)	0.008
Negative	58	18 (31.03)		30 (51.72)		10 (17.24)
Tumor stage
T1	23	0 (0)	0.005	0 (0)	0.008	0 (0)	0.006
T2	40	21 (52.50)		17 (42.50)		10 (25.00)
T3	52	46 (88.46)		40 (76.92)		27 (51.92)
T4	15	15 (100.00)		15 (100.00)		15 (100.00)
Tumor grade
G1	31	20 (64.52)	NS	13 (41.94)	0.009	3 (9.68)	0.006
G2	76	49 (64.47)		40 (52.63)		29 (38.16)
G3	23	13 (56.52)		20 (86.96)		20 (86.96)
Growth pattern
Trabecular	101	63 (62.38)	NS	54 (52.47)	NS	40 (39.60)	NS
Nontrabecular	29	19 (65.52)		19 (65.52)		12 (41.38)
Cirrhosis
Yes	86	46 (53.49)	NS	47 (54.65)	NS	34 (39.53)	NS
No	44	26 (59.09)		26 (59.09)		18 (40.91)
Underlying liver disease
Alcoholic	25	15 (60.00)	NS	15 (60.00)	NS	7 (28.0)	NS
Hepatitis B	49	28 (57.14)		28 (57.14)		18 (36.73)
Hepatitis C	35	27 (77.14)		18 (51.43)		15 (42.86)
Unknown	21	12 (57.14)		12 (57.14)		12 (57.14)

Note: “NS” refers to that the differences among groups have no statistical significance.