Prognostic Value of Combined Aquaporin 3 and Aquaporin 5 Overexpression in Hepatocellular Carcinoma

Table 3

Multivariate survival analysis of five-year overall and disease-free survival in 130 patients with hepatocellular carcinoma.

Features	Five-year overall survival			Five-year disease-free survival
	HR	95% CI	P	HR	95% CI	P
Age	1.132	0.316–3.516	0.192	1.536	0.322–3.736	0.125
Gender	1.191	0.345–3.857	0.136	1.559	0.357–3.831	0.131
Serum AFP	1.931	0.685–4.056	0.063	1.953	0.615–4.273	0.062
Tumor stage	2.879	1.366–5.196	0.009	2.686	1.386–6.009	0.01
Tumor grade	1.563	0.609–4.088	0.081	1.551	0.607–4.466	0.086
Presence of cirrhosis	1.919	0.738–4.102	0.063	1.921	0.793–4.219	0.062
AQP3 expression	5.398	1.312–11.338	0.01	5.200	1.343–11.186	0.01
AQP5 expression	8.476	1.993–17.286	0.006	5.936	1.312–12.588	0.01
AQP3/AQP5 expression	6.982	1.601–15.193	0.009	5.695	1.381–11.902	0.01