Table 2: Clinical characteristics of the Mal de Meleda patients.

Patient's characteristicsPatient in family MDM-12Patient in family MDM-13Patients in family MDM-14
Patient 1Patient 2

Age (years)4040213
Age of onsetFirst monthsFirst monthsFirst monthsFirst months
SexFMMF
Diffuse hyperkeratosis ++
Characteristics of transgressiveness ++
Elbows involvement
Knees involvement
Palmoplantar hyperhidrosis +
Malodor pachyderma ++
Nails involvement
Perioral erythema +
Keratolytic pits
Melanoma symptoms