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BioMed Research International
Volume 2013 (2013), Article ID 207181, 7 pages
http://dx.doi.org/10.1155/2013/207181
Research Article

Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors

Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran

Received 1 July 2013; Accepted 5 September 2013

Academic Editor: Hirotaka Iwase

Copyright © 2013 Hooshang Hamidian. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a–5f) showed the most potent mushroom tyrosinase inhibition (IC50 values in the range of 4.39 ± 0.76–1.71 ± 0.49 µM), comparable to the kojic acid, as reference standard inhibitor. All the novel compounds were characterized by FT-IR, 1H NMR, 13C NMR, and elemental analysis.