Protective Effects of p38 MAPK Inhibitor SB202190 against Hippocampal Apoptosis and Spatial Learning and Memory Deficits in a Rat Model of Vascular Dementia

Table 1

Comparison of escape latencies in Morris water maze learning trials among treatment groups.

Groups	Day 1	Day 2	Day 3
Sham-operated	24.17±4.12	21.59±5.13	16.83±3.77^ΔΔ
Model	82.71±8.27^∗∗	80.36±9.65^∗∗	77.74±6.33^∗∗
SB202190	48.72±7.01^∗∗##	42.41±4.06^∗∗##	40.34±2.46^∗∗##Δ

Note. Data are expressed as means ± standard deviation (SD) (𝑛=8); **𝑃<0.01 versus sham-operated group, ^##𝑃<0.01 SB202190 group versus model group, ^Δ𝑃<0.05, ^ΔΔ𝑃<0.01 versus Day 1.