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BioMed Research International
Volume 2013 (2013), Article ID 215989, 9 pages
http://dx.doi.org/10.1155/2013/215989
Clinical Study

Estimation of the Lateral Ventricles Volumes from a 2D Image and Its Relationship with Cerebrospinal Fluid Flow

1Department of Imaging, Jules Verne University of Picardy and Amiens University Hospital, 80054 Amiens Cedex, France
2Department of Neurosurgery, Jules Verne University of Picardy and Amiens University Hospital, 80054 Amiens Cedex, France
3Department of Geriatrics, Jules Verne University of Picardy and Amiens University Hospital, 80054 Amiens Cedex, France
4Department of Radiology, Jules Verne University of Picardy and Amiens University Hospital, 80054 Amiens Cedex, France

Received 26 March 2013; Accepted 12 August 2013

Academic Editor: Tosiaki Miyati

Copyright © 2013 Chaarani Bader et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. This work suggests a fast estimation method of the lateral ventricles volume from a 2D image and then determines if this volume is correlated with the cerebrospinal fluid flow at the aqueductal and cerebral levels in neurodegenerative diseases. Materials and Methods. FForty-five elderly patients suffering from Alzheimer’s disease (19), normal pressure hydrocephalus (13), and vascular dementia (13) were involved and underwent anatomical and phase contrast MRI scans. Lateral ventricles and stroke volumes were assessed on anatomical and phase contrast scans, respectively. A common reference plane was used to calculate the lateral ventricles’ area on 2D images. Results. The largest volumes were observed in hydrocephalus patients. The linear regression between volumes and areas was computed, and a strong positive correlation was detected ( ). A derived equation was determined to represent the volumes for any given area. On the other hand, no significant correlations were detected between ventricles and stroke volumes ( ). Conclusion. Lateral ventricles volumes are significantly proportional to the 2D reference section area and could be used for patients’ follow-up even if 3D images are unavailable. The cerebrospinal fluid fluctuations in brain disorders may depend on many physiological parameters other than the ventricular morphology.