Doxycycline Prevents Intimal Hyperplasia In Vitro and May Improve Patency of the Internal Thoracic Artery

Figure 2

Histologic sections of cultured internal thoracic arteries showing the development of neointima (arrow) in segments from control (A) and doxycycline-treated arteries (B). Combined smooth-muscle actin and elastin stain. The endothelium is intact (C) at the end of the 2-week period of culture (arrow).