Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis:  Focus on Matrix Metalloproteinases, Their Endogenous  Tissue Inhibitors, and the Proteasome

<table>Hypothetical model of the molecular mechanisms that control periprosthetic microenvironment and potential molecular targeting with regard to the expression and activity of MMPs/TIMPs to prevent osteolysis  <i>(see text for details)</i>.</table>

BioMed Research International

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Figure 2: Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis:  Focus on Matrix Metalloproteinases, Their Endogenous  Tissue Inhibitors, and the Proteasome 

Figure 2 | Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis:  Focus on Matrix Metalloproteinases, Their Endogenous  Tissue Inhibitors, and the Proteasome 