Table 1: Matrix metalloproteinases (MMPs) in periprosthetic microenvironment (expression and/or activity: ↑ with bold data: high; ↑ without bold data: moderate).

MMPsSubstratesExpression and/or activity in periprosthetic microenvironment [References]

Collagenases
Contain hemopexin domain and peptide linking with catalytic domainMMP-1  (interstitial collagenase; collagenase 1) 
MMP-8  (neutrophil collagenase; collagenase 2) 
MMP-13  (collagenase 3)
Collagen type I, III, V, VII, VIII, X, gelatin, IL-1β, MMP-2, -9, fibronectin↑MMP-1  [39, 58, 70, 72, 80, 82, 90]
↑MMP-8 [70]
↑MMP-13  [70, 82, 89]

Gelatinases
High substrate specificity to native collagen and gelatinMMP-2  (gelatinase A; 72 kDa metalloproteinase) 
MMP-9  (gelatinase B; 92 kDa metalloproteinase)
Collagen type IV, V, VII, X, proteoglycans, gelatin, elastin, laminin↑MMP-2  [58, 70, 73, 74, 76, 77, 80, 90]
↑MMP-9  [58, 70, 76, 77, 80, 90, 91]

Stromelysins
Metalloproteinases of stromaMMP-3  (stromelysin 1) 
MMP-10  (stromelysin 2) 
MMP-11  (stromelysin 3)
Proteoglycans, fibronectin, laminin, elastin, gelatin, plasminogen, vitronectin, fibrinogen, fibrin, collagen type III, IV, V, antithrombin III, MMP-1, -2, -8, -9, -13↑MMP-3 [58, 70, 74, 80]
↑MMP-10  [70]
↑MMP-11 [70]

Matrilysins
The smallest among MMPs, lack of hemopexin domainMMP-7  (matrilysin, metalloendopeptidase) 
MMP-26  (matrilysin-2, endometase)
Collagen type IV, proteoglycans, glycoproteins, gelatin↑MMP-7 [70]

Membrane-type MMPs
(A)  Transmembrane-type MMPsMMP-14  (MT1-MMP) 
MMP-15  (MT2-MMP) 
MMP-16  (MT3-MMP) 
MMP-24  (MT5-MMP)
Collagen type I, II, III, gelatin, elastin, laminin, fibronectin, fibrin, proteoglycans, proMMP-2, proMMP-13↑MMP-14  [70, 73]
↑MMP-15 [70]
↑MMP-16 [70]
(B) GPI-anchored MMPsMMP-17  (MT4-MMP) 
MMP-25  (MT6-MMP)
↑MMP-17 [70]

Other MMPs
MMPs that are not categorized in any of the previous groupsMMP-12  (macrophage metalloelastase) 
MMP-19
MMP-20  (enamelysin) 
MMP-21,  MMP-23
MMP-27,  MMP-28
↑MMP-12  [70]
↑MMP-19 [70]