Table 2: Tissue inhibitors of metalloproteinases (TIMPs) in periprosthetic microenvironment (expression and/or activity: ↑ with bold data: high; without bold data: low).

TIMPsPreferred MMP/ADAM/ADAMTSExpression and/or activity in periprosthetic microenvironment [References]

TIMP-1Most MMPs, ADAM-10 (inhibition). MT3-MMP, MT5-MMP, MMP-19 (weak inhibition)↑TIMP-1 [71, 74, 76, 78, 80, 82]
TIMP-2Most MMPs (inhibition). MMP-2 (activation)↑TIMP-2 [71, 73, 76, 80, 82]
TIMP-3Most MMPs, ADAM-10, -12, -17, and ADAMTS-1, -4, -5 (inhibition). MMP-2, MT3-MMP (activation)↑TIMP-3 [71]
TIMP-4Most MMPs (inhibition) TIMP-4 [71]