A Simple Model for Assessment of Anti-Toxin Antibodies

Figure 7

Establishment of the quasi-equilibrium state in the presence of antibody. 𝐶_𝑅 formation (△) was simulated using COPASI and the kinetic constants in Table 1. Γ (□) was determined using (25) and values 𝑇_𝑖 and 𝑇⁰_𝑖 at 𝑡=10⁴ sec using simulated toxin internalization time courses. 𝑅₀=5 nM, 𝑇₀=10 pM, 𝐶₀=1.15⋅10⁻⁷, 𝜆=0.05.