About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 231378, 9 pages
http://dx.doi.org/10.1155/2013/231378
Research Article

Potential Utility of Sodium Selenate as an Adjunct to Metformin in Treating Type II Diabetes Mellitus in Rats: A Perspective on Protein Tyrosine Phosphatase

1Pharmacology Department, Faculty of Pharmacy, Misr International University (MIU), KM 28 Cairo-Ismailia Road (Ahmed Orabi District), Cairo, Egypt
2Biochemistry Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt
3Pharmacology Department, Faculty of Medicine, Assiut University, Cairo, Egypt
4Pharmacology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

Received 17 April 2013; Accepted 12 August 2013

Academic Editor: Ali Rizvi

Copyright © 2013 Rania M. Salama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Roglic and N. Unwin, “Mortality attributable to diabetes: estimates for the year 2010,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 15–19, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. International Diabetes Federation (IDF, 2009): Diabetes Atlas fourth edition.
  3. S. Schinner, W. A. Scherbaum, S. R. Bornstein, and A. Barthel, “Molecular mechanisms of insulin resistance,” Diabetic Medicine, vol. 22, no. 6, pp. 674–682, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Basciano, L. Federico, and K. Adeli, “Fructose, insulin resistance, and metabolic dyslipidemia,” Nutrition and Metabolism, vol. 2, no. 1, article 5, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. D. Kim, K.-G. Park, Y.-S. Lee et al., “Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP,” Diabetes, vol. 57, no. 2, pp. 306–314, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. N. F. Wiernsperger and C. J. Bailey, “The antihyperglycaemic effect of metf ormin therapeutic and cellular mechanisms,” Drugs, vol. 58, supplement 1, pp. 31–39, 1999. View at Scopus
  7. G. Zhou, R. Myers, Y. Li et al., “Role of AMP-activated protein kinase in mechanism of metformin action,” Journal of Clinical Investigation, vol. 108, no. 8, pp. 1167–1174, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. J. H. McNeill, H. L. M. Delgatty, and M. L. Battell, “Insulinlike effects of sodium selenate in streptozocin-induced diabetic rats,” Diabetes, vol. 40, no. 12, pp. 1675–1678, 1991. View at Scopus
  9. D. J. Becker, B. Reul, A. T. Ozcelikay, J. P. Buchet, J.-C. Henquin, and S. M. Brichard, “Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats,” Diabetologia, vol. 39, no. 1, pp. 3–11, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. K. A. Kenner, E. Anyanwu, J. M. Olefsky, and J. Kusari, “Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling,” Journal of Biological Chemistry, vol. 271, no. 33, pp. 19810–19816, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. A. S. Mueller and J. Pallauf, “Compendium of the antidiabetic effects of supranutritional selenate doses. In vivo and in vitro investigations with type II diabetic db/db mice,” Journal of Nutritional Biochemistry, vol. 17, no. 8, pp. 548–560, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Srinivasan, B. Viswanad, L. Asrat, C. L. Kaul, and P. Ramarao, “Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening,” Pharmacological Research, vol. 52, no. 4, pp. 313–320, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Matthaei, J. P. Reibold, A. Hamann et al., “In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes,” Endocrinology, vol. 133, no. 1, pp. 304–311, 1993. View at Publisher · View at Google Scholar · View at Scopus
  14. E. A. Berg, J. Y. Wu, L. Campbell, M. Kagey, and S. R. Stapleton, “Insulin-like effects of vanadate and selenate on the expression of glucose-6-phosphate dehydrogenase and fatty acid synthase in diabetic rats,” Biochimie, vol. 77, no. 12, pp. 919–924, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. M. M. Nader, L. A. Eissa, N. M. Gamil, and E.-S. M. Ammar, “Effect of nitric oxide, vitamin E and selenium on streptozotocin induced diabetic rats,” Saudi Pharmaceutical Journal, vol. 15, no. 1, pp. 23–32, 2007. View at Scopus
  16. A. Psyrogiannis, V. Kyriazopoulou, A. Symeonidis, M. Leotsinidis, and A. G. Vagenakis, “Relative iron, ‘overload: in offspring of patients with type 2 diabetes mellitus: a new component in the conundrum of insulin resistance syndrome?’,” Hormones(Athens), vol. 2, no. 3, pp. 161–168, 2003.
  17. P. Trinder, “Determination of blood glucose using 4-amino phenazone as oxygen acceptor,” Journal of Clinical Pathology, vol. 22, no. 2, article 246, 1969. View at Scopus
  18. C. R. Morgan and A. Lazarow, “Immunoassay of insulin using a two-antibody system,” Proceedings of the Society for Experimental Biology and Medicine, vol. 110, pp. 29–32, 1962. View at Scopus
  19. D. R. Matthews, J. P. Hosker, and A. S. Rudenski, “Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Scopus
  20. C. C. Allain, L. S. Poon, and C. S. G. Chan, “Enzymatic determination of total serum cholesterol,” Clinical Chemistry, vol. 20, no. 4, pp. 470–475, 1974. View at Scopus
  21. A. W. Wahlefeld, “Triglycerides determination after enzymatic hydrolysis,” in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., pp. 1831–1835, Academic Press, New York, NY, USA, 1974.
  22. C. Matsubara, Y. Nishikawa, Y. Yoshida, and K. Takamura, “A spectrophotometric method for the determination of free fatty acid in serum using acyl-coenzyme A synthetase and acyl-coenzyme A oxidase,” Analytical Biochemistry, vol. 130, no. 1, pp. 128–133, 1983. View at Scopus
  23. Y. Nakano, S. Tajima, A. Yoshimi et al., “A novel enzyme-linked immunosorbent assay specific for high-molecular- weight adiponectin,” Journal of Lipid Research, vol. 47, no. 7, pp. 1572–1582, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Scopus
  25. E. Beutler, O. Duron, and B. M. Kelly, “Improved method for the determination of blood glutathione,” The Journal of Laboratory and Clinical Medicine, vol. 61, pp. 882–888, 1963. View at Scopus
  26. P. A. Lanzetta, L. J. Alvarez, P. S. Reinach, and O. A. Candia, “An improved assay for nanomole amounts of inorganic phosphate,” Analytical Biochemistry, vol. 100, no. 1, pp. 95–97, 1979. View at Scopus
  27. E. Y. Sözmen, B. Sözmen, Y. Delen, and T. Onat, “Catalase/superoxide dismutase (SOD) and catalase/paraoxonase (PON) ratios may implicate poor glycemic control,” Archives of Medical Research, vol. 32, no. 4, pp. 283–287, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. O. O. Erejuwa, S. A. Sulaiman, M. S. A. Wahab, K. N. S. Sirajudeen, M. S. M. Salleh, and S. Gurtu, “Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats,” International Journal of Biological Sciences, vol. 7, no. 2, pp. 244–252, 2011. View at Scopus
  29. P. Bansal, P. Paul, J. Mudgal et al., “Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice,” Experimental and Toxicologic Pathology, vol. 64, no. 6, pp. 651–658, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Matafome, T. Louro, L. Rodrigues et al., “Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia,” Diabetes/Metabolism Research and Reviews, vol. 27, no. 1, pp. 54–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Hu, X. Li, L. Zhao, S. Feng, and C. Wang, “Antidiabetic properties of purified polysaccharide from Hedysarum polybotrys,” Canadian Journal of Physiology and Pharmacology, vol. 88, no. 1, pp. 64–72, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Da Silva Xavier, I. Leclerc, A. Varadi, T. Tsuboi, S. K. Moule, and G. A. Rutter, “Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression,” Biochemical Journal, vol. 371, no. 3, pp. 761–774, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Zhang and K.-H. Kim, “Glucose activation of acetyl-CoA carboxylase in association with insulin secretion in a pancreatic β-cell line,” Journal of Endocrinology, vol. 147, no. 1, pp. 33–41, 1995. View at Scopus
  34. P. S. Haddad, A. Benhaddou-Andaloussi, L. Martineau et al., “The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 538671, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. K. W. Ong, A. Hsu, L. Song, D. Huang, and B. K. H. Tan, “Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 598–607, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. G. B. Behera, A. N. Kurnool, M. Baidya, B. S. Kumar, and S. Bilal, “Anti-hyperglyceamic, anti-hyperlipidemic and antioxidant activity of the stem of Glinus Oppositifolius (L.) AUG. DC,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, no. 1, pp. 1080–1090, 2011.
  37. X.-K. Zheng, Y.-J. Li, L. Zhang, W.-S. Feng, and X. Zhang, “Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 531–537, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. C. Metais, F. Forcheron, P. Abdallah et al., “Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin,” Metabolism, vol. 57, no. 7, pp. 946–953, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. A. A. Alhaider, H. M. Korashy, M. M. Sayed-Ahmed, M. Mobark, H. Kfoury, and M. A. Mansour, “Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression,” Chemico-Biological Interactions, vol. 192, no. 3, pp. 233–242, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. W. Holland, T. Morrison, Y. Chang, N. Wiernsperger, and B. J. Stith, “Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase,” Biochemical Pharmacology, vol. 67, no. 11, pp. 2081–2091, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Kannappan and C. V. Anuradha, “Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model,” Indian Journal of Medical Research, vol. 129, no. 4, pp. 401–408, 2009. View at Scopus
  42. S. Roy, S. K. Dontamalla, A. K. Mondru, S. Sannigrahi, and P. R. Veerareddy, “Downregulation of apoptosis and modulation of TGF-β1 by sodium selenate prevents streptozotocin-induced diabetic rat renal impairment,” Biological Trace Element Research, vol. 139, no. 1, pp. 55–71, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Aydemir-Koksoy, A. Bilginoglu, M. Sariahmetoglu, R. Schulz, and B. Turan, “Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress,” Journal of Nutritional Biochemistry, vol. 21, no. 9, pp. 827–833, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Bloch-Damti and N. Bashan, “Proposed mechanisms for the induction of insulin resistance by oxidative stress,” Antioxidants and Redox Signaling, vol. 7, no. 11-12, pp. 1553–1567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. A. S. Mueller, J. Pallauf, and J. Rafael, “The chemical form of selenium affects insulinomimetic properties of the trace element: investigations in type II diabetic dbdb mice,” Journal of Nutritional Biochemistry, vol. 14, no. 11, pp. 637–647, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. Iizuka, Y. Ueda, Y. Yagi, and E. Sakurai, “Significant improvement of insulin resistance of GK rats by treatment with sodium selenate,” Biological Trace Element Research, vol. 138, no. 1–3, pp. 265–271, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. U. Bayraktutan, “Free radicals, diabetes and endothelial dysfunction,” Diabetes, Obesity and Metabolism, vol. 4, no. 4, pp. 224–238, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. E. Bakopanos and J. E. Silva, “Thiazolidinediones inhibit the expression of β3-adrenergic receptors at a transcriptional level,” Diabetes, vol. 49, no. 12, pp. 2108–2115, 2000. View at Scopus
  49. D. Szalkowski, S. White-Carrington, J. Berger, and B. Zhang, “Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells,” Endocrinology, vol. 136, no. 4, pp. 1474–1481, 1995. View at Scopus
  50. U. Kintscher and T. Unger, “Vascular protection in diabetes: a pharmacological view of angiotensin II type 1 receptor blockers,” Acta Diabetologica, vol. 42, no. 1, pp. S26–S32, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. R. Brigelius-Flohé, “Tissue-specific functions of individual glutathione peroxidases,” Free Radical Biology and Medicine, vol. 27, no. 9-10, pp. 951–965, 1999. View at Publisher · View at Google Scholar · View at Scopus
  52. A. S. Müller, E. Most, and J. Pallauf, “Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice,” Journal of Animal Physiology and Animal Nutrition, vol. 89, no. 3–6, pp. 94–104, 2005. View at Publisher · View at Google Scholar · View at Scopus