Potential Utility of Sodium Selenate as an Adjunct to Metformin in Treating Type II Diabetes Mellitus in Rats: A Perspective on Protein Tyrosine Phosphatase

Table 3

Effect of daily administration of metformin (250 mg/kg; p.o.) [DIR + Met], sodium selenate (1.89 mg/kg; i.p.) [DIR + Sel], and metformin (250 mg/kg; p.o.) plus sodium selenate (1.89 mg/kg; i.p.) [DIR + Met + Sel] on serum content of adiponectin as well as hepatic content of GSH and activity of PTP using DIR rats.

Groups	Parameter
	Serum adiponectin (ng/mL)	Liver GSH (mg/dL)	Liver PTP (pmol/mg protein)
Control	1.975 ± 0.224	33.576 ± 1.810	10.812 ± 0.169
DIR	0.712 ± 0.035^c	8.283 ± 0.459^c	19.518 ± 0.327^c
DIR + Met	0.849 ± 0.083^c	28.399 ± 1.464^af	16.800 ± 0.250^cf
DIR + Sel	0.940± 0.054^c	28.840 ± 1.530^af	11.875 ± 0.459^af
DIR + Met + Sel	0.955 ± 0.032^c	30.614 ± 1.759^f	11.800 ± 0.427^afi

Values represent the mean of 8 rats ± SEM (one-way ANOVA followed by LSD test).
^a𝑃<0.05, ^c𝑃<0.001 compared to the control group. ^f𝑃<0.001 compared to DIR group. ⁱ𝑃<0.001 compared to DIR + Met group.