Exploring Different Virtual Screening Strategies for Acetylcholinesterase Inhibitors

Table 2

Comparison of AChE and BuChE selectivity of the selected ligands for similarity search analysis.

S. No.	Compound	AChE 𝐾𝑖 (nM)	BuChE 𝐾𝑖 (nM)
(1)	Donepezil	2.9	640
(2)	Huperzine	0.026	120
(3)	Tacrine	7	6.9
(4)	Edrophonium	1.6	340000
(5)	Rivastigmine	37	37