An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation

Figure 2

Cybrid cell lines with the T6124C mutation show increased proliferation. Proliferation was measured in 3 separate 6124WT clones and 3 separate 6124Mut clones using FluoReporter Blue Fluorometric dsDNA Quantitiation Kit (see Section 2). Symbols represent the following clones: ◊-6124WT3; ◯-6124WT5; □-6124WT6, ◆-6124Mut1; ⚫-6124Mut2; ■-6124Mut4. Error bars represent the standard error of the mean of triplicate data.