An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation
Table 1
Patient mitochondrial DNA mutations. Patient peripheral blood, lymphoblast, and cybrid mtDNA was sequenced in its entirety. All changes from rCRS are shown as is the region in which the change occurs and the amino acid alteration when applicable. AI (allelic index) is the measure of the frequency of the mutation when compared to mtDB—Human Mitochondrial Genome Database [16]. Cybrid mtDNA was identical to peripheral blood with the exception of n.p. 6124 at which point the cybrids were determined to be either homoplasmic mutant or wild type.
