Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase

Table 1

Physical constants of the curcumin analogues (1–14).

Compound	R	X	NSC code	Yield (%)	Mp (°C)
1	2-Chloro	—	763372	76	92
2	4-Chloro	—	757924	66	78
3	4-Fluoro	—	757925	72	70
4	4-Bromo	—	—	74	136
5	3-Chloro-4-fluoro	—	757927	78	58
6	4-Methyl	—	763373	82	60
7	2-Methyl	—	—	71	98
8	2,4-Dimethyl	—	757926	88	68
9	2,6-Dimethyl	—	—	82	166
10	H	—	757929	84	110
11	2-Bromo	—	757928	76	288
12	—	O	763374	72	104
13	—	NH	763375	78	82
14	—	S	—	—	—