Table 3: NCI in vitro testing results of compounds of the compounds 8, 10, and 13 at five-dose level in µM.

S. no.Panel/cell line8 (NSC 757926)10 (NSC 757929)13 (NSC 763375)
GI50TGILC50GI50TGILC50GI50TGILC50

(1)Leukemia
 CCRF-CEM0.232>100>1000.127>100>1000.543NT>100
 HL-60(TB)0.2370.806>1000.0884NT>1002.186.17>100
 MOLT-40.364NT>1000.347>100>1001.015.19>100
 RPMI-82260.336NT>1000.275NT>1001.294.18>100
 SR0.004>100>1000.0353>100>1000.723.58>100
(2)Non-small cell lung cancer
 A549/ATCC0.4453.6356.30.4031.91>1002.226.0476.4
 EKVX0.7715.51>1000.7022.38NT2.226.83>100
 HOP-62 0.4971.634.210.4411.624.231.964.28NT
 HOP-92 0.5383.39>1000.353.32>1001.265.19>100
 NCI-H2260.3892.112.90.3821.837.681.834.3412
 NCI-H23 0.2751.25>1000.1131.61>1001.84.24NT
 NCI-H322M 0.5712.885.80.6152.49NT2.225.39>100
 NCI-H460 0.306NT>1000.274NT>1002.055.20>100
 NCI-H5220.130.616NT0.2867.59NT1.242.796.31
(3)Colon cancer
 COLO 2052.053.626.381.863.345.971.83.245.85
 HCC-29980.645.8>1000.5912.71>1001.753.195.79
 HCT-1160.323NTNT0.2691.14NT1.12.395.18
 HCT-150.3351.66NT0.1671.52NT2.8210.3>100
 HT290.6962.89.940.4633.19>1003.140.9484.21
 KM120.2981.25NT0.00921.19NT1.633.326.79
 SW-6200.441NT>1000.0079NT>1001.653.68NT
(4)CNS cancer
 SF-2680.571NTNT0.256NTNT2.1115.6>100
 SF-2950.546NT>1000.538NTNT1.934.54>100
 SF-5390.3541.5NT0.06041.53NT2.055.73>100
 SNB-190.6342.01NT0.5722.12NT1.817.95>100
 SNB-750.4161.82NT0.00991.87NT1.263.348.84
 U2510.4711.59NT0.4281.70NT1.795.696.63
(5)Melanoma
 LOX IMVI0.2841.49NT0.06261.56NT1.272.59NT
 MALME-3M0.5631.98NT0.5252.17NT2.716.76>100
 M140.3721.41NT0.1551.48NT1.653.44NT
 MDA-MB-4350.04480.383NT0.01750.00815>1001.71NT>100
 SK-MEL-20.3661.82NT0.2662.03>1001.984.1NT
 SK-MEL-280.5092.478.610.1762.729.051.854.5326
 SK-MEL-50.3171.293.670.1711.303.691.492.895.59
 UACC-2571.545.4731.91.144.2953.31.533.58
 UACC-620.4131.654.890.3711.64NT1.493.23NT
(6)Ovarian cancer
 IGROV10.4542.62>1000.483NT>1002.957.08>100
 OVCAR-30.4121.72>1000.2421.16>1002.658.6263.5
 OVCAR-40.4813.32>1000.5306.76>1001.7111.571.1
 OVCAR-51.516.85>1001.274.51>1002.034.339.22
 OVCAR-80.5632.359.710.4793.78>1002.197.24>100
 NCI/ADR-RES0.3384.01>1000.08743.85>1002.8818.8>100
 SK-OV-30.4191.67.280.3581.353.882.68.23>100
(7)Renal cancer
 786-00.5491.764.610.6882.034.991.74NT
 A4980.5751.984.630.69724.651.513.267.04
 ACHN0.4122.11>1000.1311.69NT2.547.88>100
 CAKI-10.3415.49>1000.2823.24>1002.236.46>100
 RXF 3930.2270.6532.720.2630.8783.601.53.2NT
 SN 12C0.3391.88NT0.3132.20>1002.74>100>100
 TK-100.42427.150.4461.765.193.399.545.34
 UO-310.3621.745.930.2581.654.732.097.57>100
(8)Prostate cancer
 PC-30.3495.78>1000.33112.7>1001.485.57>100
 DU-1450.4191.44NT0.3891.51NT2.46.3188
(9)Breast cancer
 MCF70.3171.374.860.1621.66.571.816.3338.8
 MDA-MB-231/ATCC0.4734.71>1000.4044.83>1001.454.08>100
 HS 578T0.295>100>1000.0779>100>1000.5242.99>100
 BT-5490.69316.8>1000.63122.8>1001.33.52NT
 T-47D0.792.94NT0.7932.939.792.839.55>100
 MDA-MB-4680.2480.82563.10.2760.969>100NTNTNT

NT: not tested.