Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(<i>ε</i>-caprolactone), and Itaconic Acid

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Motor activities</td><td align="left">Restlessness, hyperactivity, and phonation</td></tr><tr><td align="left">Symptoms of nervous system</td><td align="left">Tail erect, tremble, spasm, movement disorder, and gesture abnormal</td></tr><tr><td align="left">Symptoms of autonomic Nervous system</td><td align="left">Protrusion of eyeballs, salivation, weep, urination, diarrhea, hair bristled up, and discoloration, dyspnea</td></tr><tr><td align="left">mortality</td><td align="left">Death</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Toxicity signs not observed in BALB/c mice treated with P(ECA-IA-MEG) hydrogel.

BioMed Research International

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Table 3

Table 3: Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(<i>ε</i>-caprolactone), and Itaconic Acid 

Table 3 | Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid 