MDR Gene Expression Analysis of Six Drug-Resistant Ovarian Cancer Cell Lines
Table 2
Summary of cell line cross-resistance to drug treatment.
Cell line
IC50 (ng/mL)
Methotrexate
Cisplatin
Doxorubicin
Vincristine
Topotecan
Paclitaxel
7.02
253
20.8
1.85
4.19
3.54
W1
(5.85–8.58)
(231–270)
(20.5–21.1)
(1.82–1.87)
(3.55–4.95)
(3.47–3.65)
1
1
1
1
1
1
970
168
17.0
1.53
2.72
3.19
W1MR
(858–1086)
(161–174)
(12.4–21.5)
(1.42–1.60)
(2.55–2.81)
(2.77–3.73)
138
***
0.66
**
0.82
0.83
**
0.65
*
0.90
9.00
1991
23.3
2.57
5.66
4.43
W1CR
(6.80–8.12)
(1630–2470)
(20.5–24.5)
(1.66–3.53)
(5.07–6.55)
(3.43–5.55)
1.28
7.87
***
1.12
1.39
1.35
1.25
6.00
258
215
106
6.4
109
W1DR
(5.90–6.60)
(213–337)
(165–248)
(30.5–131)
(5.67–7.44)
(76.6–152)
0.85
1.02
10.3
***
57.3
↑**
1.52
*
30.8
***
7.53
320
132
45.3
6.35
64.8
W1VR
(6.10–9.70)
(243–422)
(92–167)
(24.4–65.6)
(4.69–7.74)
(44.6–85.6)
1.07
1.26
6.35
***
24.5
↑***
1.52
18.3
***
39
374
30.9
2.34
83.9
4.24
W1TR
(22–67)
(285–451)
(21.6–33.9)
(1.68–3.10)
(70.9–98)
(3.92–4.86)
5.55
*
1.48
1.49
1.26
20.0
***
1.20
7.53
383
4241
1155
80.2
2268
W1PR
(5.9–8.4)
(366–413)
(3136–5624)
(548–2100)
(72.5–92.8)
(1868–2788)
1.07
1.51
**
204
***
624
***
19.1
***
641
***
IC50 mean is indicated for each drug. The drug resistance in W1 cell line was assigned as 1. Underlined values indicate multiplicities of resistance with respect to W1 cell line. *; **; ***.
