Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes

<table>Activation of MPTP to the directly acting neurotoxin MPP+, which is uptaken by dopaminergic cells via DAT (dopamine active transporter) and produces neurotoxicity and cell death. β-Carbolinium cations (βC+) are toxic analogs of MPP+ that may arise from 2-methyl-1,2,3,4-tetrahydro-β-carbolines. </table>

BioMed Research International

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Figure 1

Figure 1: Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes

Figure 1 | Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine  and 2-Methyltetrahydro-β-carboline  by Oxidative Enzymes 