Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes
Figure 4
Metabolites and rates produced from MPTP neurotoxin (50 and 250 μM) by human MAO-B (0.05 mg/mL protein) (a) and human cytochrome P450 2D6 (b) and (c). Enzyme assays were as indicated in experimental section.
