248608.fig.006a
(a) P450 2D6
248608.fig.006b
(b) Heme peroxidases
248608.fig.006c
(c) Heme peroxidases
Figure 6: Metabolites and rates produced from 2-methyl-1,2,3,4-tetrahydro-β-carboline (2-Me-THβC) by cytochrome P450 2D6 (a) and lactoperoxidase (LPO) and myeloperoxidase (MPO) (b). (c) Corresponds to the formation of MPP+ from MPDP+ as catalyzed by peroxidases LPO and MPO (the corresponding controls with H2O2 and no enzyme are subtracted). Enzyme assays were as indicated in experimental section.