Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma

Figure 4

Effect of pretreatment with anti-IL-33 or a control antibody to β-galactosidase on the airway inflammatory response. (a) Relative accumulation of eosinophils, assessed by eosinophil peroxidase activity. (b) Number of neutrophils in lung tissue, assessed by immunostaining. (c) Concentration of IL-6 in BAL fluid. (d) Concentration of CXCL-1 in BAL fluid. Data are mean ± SEM (𝑛=6 samples per group). Significant differences relative to the naïve group are shown as ^∗(𝑃<0.05), ^∗∗(𝑃<0.01), and ^∗∗∗(𝑃<0.001) and those relative to the control antibody-treated group are shown as ^#(𝑃<0.05), ^##(𝑃<0.01), and ^###(𝑃<0.001).

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