Research Article
Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma
Table 1
Flow cytometric assessment of activation markers by AM.
| Marker | Percentage of F4/80+ AM staining positive | Mean fluorescence intensity (relative units) | Naïve | Acute exacerbation | Naïve | Acute exacerbation |
| CD11b | 3.43 ± 0.16 | 9.72 ± 1.62** | 48.73 ± 5.27 | 95.53 ± 13.49** | CD11c | 88.37 ± 1.06 | 92.05 ± 0.61* | 81.97 ± 1.62 | 140.0 ± 4.93*** | CD14 | 98.90 ± 0.12 | 98.17 ± 0.15 | 45.67 ± 0.68 | 190.8 ± 2.68*** | CD16 | 98.18 ± 0.15 | 54.48 ± 1.70*** | 32.37 ± 0.82 | 19.97 ± 0.58*** | CD23 | 4.31 ± 0.33 | 5.85 ± 0.14** | 28.94 ± 0.31 | 28.38 ± 0.28 | CD64 | 74.08 ± 1.74 | 62.77 ± 1.52** | 15.93 ± 0.28 | 16.37 ± 0.37 | CD80 | 81.83 ± 1.06 | 76.42 ± 0.58 | 17.12 ± 0.24 | 17.75 ± 0.17 | CD86 | 61.35 ± 1.40 | 70.60 ± 1.92** | 19.58 ± 0.21 | 29.83 ± 0.47*** | MHCII | 31.33 ± 1.62 | 55.93 ± 1.88*** | 171.8 ± 2.12 | 460.8 ± 22.34*** |
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Data are mean ± SEM ( animals per group). Significant differences relative to naïve animals are shown as *(), **(), and ***().
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